Luban, Jeremy2022-08-232022-08-232012-10-182018-05-10<p>Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002. <a href="https://doi.org/10.1016/j.chom.2012.10.002">Link to article on publisher's site</a></p>1931-3128 (Linking)10.1016/j.chom.2012.10.00223084911https://hdl.handle.net/20.500.14038/44483HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.en-USAmino Acids, Peptides, and ProteinsImmunityImmunology of Infectious DiseaseMolecular BiologyVirologyVirusesJournal Articlehttps://escholarship.umassmed.edu/pmm_pp/7912103890pmm_pp/79