Kundu, AmartyaO'Day, KevinShaikh, Amir Y.Lessard, Darleen MSaczynski, Jane S.Yarzebski, Jorge L.Darling, Chad E.Thabet, RamsesAkhter, Mohammed W.Floyd, Kevin C.Goldberg, Robert J.McManus, David D2022-08-232022-08-232016-04-152016-08-31<p>Am J Cardiol. 2016 Apr 15;117(8):1213-8. doi: 10.1016/j.amjcard.2016.01.012. Epub 2016 Jan 28. <a href="http://dx.doi.org/10.1016/j.amjcard.2016.01.012">Link to article on publisher's site</a></p>0002-9149 (Linking)10.1016/j.amjcard.2016.01.01226874548https://hdl.handle.net/20.500.14038/50511Atrial fibrillation (AF) is a common complication of acute myocardial infarction (AMI) and contributes to high rates of in-hospital adverse events. However, there are few contemporary studies examining rates of AF in the contemporary era of AMI or the impact of new-onset AF on key in-hospital and postdischarge outcomes. We examined trends in AF in 6,384 residents of Worcester, Massachusetts, who were hospitalized with confirmed AMI during 7 biennial periods between 1999 and 2011. Multivariate logistic regression analysis was used to examine associations between occurrence of AF and various in-hospital and postdischarge complications. The overall incidence of AF complicating AMI was 10.8%. Rates of new-onset AF increased from 1999 to 2003 (9.8% to 13.2%), and decreased thereafter. In multivariable adjusted models, patients developing new-onset AF after AMI were at a higher risk for in-hospital stroke (odds ratio [OR] 2.5, 95% confidence interval [CI] 1.6 to 4.1), heart failure (OR 2.0, 95% CI 1.7 to 2.4), cardiogenic shock (OR 3.7, 95% CI 2.8 to 4.9), and death (OR 2.3, 95% CI 1.9 to 3.0) than patients without AF. Development of AF during hospitalization for AMI was associated with higher rates of readmission within 30 days after discharge (21.7% vs 16.0%), but no significant difference was noted in early postdischarge 30-day all-cause mortality rates (8.3% vs 5.1%). In conclusion, new-onset AF after AMI is strongly related to in-hospital complications of AMI and higher short-term readmission rates.en-USUMCCTS fundingCardiologyCardiovascular DiseasesClinical EpidemiologyEpidemiologyTranslational Medical ResearchJournal Articlehttps://escholarship.umassmed.edu/umccts_pubs/809058436umccts_pubs/80