Bernstein, Elana J.Schmidt-Lauber, ChristianKay, Jonathan2022-08-232022-08-232012-08-012015-04-17Best Pract Res Clin Rheumatol. 2012 Aug;26(4):489-503. doi: 10.1016/j.berh.2012.07.008. <a href="http://dx.doi.org/10.1016/j.berh.2012.07.008">Link to article on publisher's site</a>1521-6942 (Linking)10.1016/j.berh.2012.07.00823040363https://hdl.handle.net/20.500.14038/48730Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.en-USContractureContrast MediaDiagnosis, DifferentialGadoliniumHumansHyperpigmentationNephrogenic Fibrosing DermopathyinducedRenal Insufficiency, ChronicRisk FactorsSkinMusculoskeletal DiseasesRheumatologySkin and Connective Tissue DiseasesJournal Articlehttps://escholarship.umassmed.edu/rheumatology_pubs/1377002969rheumatology_pubs/137