Strambio-De-Castillia, Caterina2022-08-232022-08-232013-03-012013-07-09<p>Nucleus. 2013 Mar-Apr;4(2):95-9. doi: 10.4161/nucl.24237. Epub 2013 Mar 1. <a href="http://dx.doi.org/10.4161/nucl.24237">Link to article on publisher's site</a></p>1949-1042 (Linking)10.4161/nucl.2423723528257https://hdl.handle.net/20.500.14038/29497The nuclear envelope forms a cocoon that surrounds the cellular genome keeping it out of harm's way and can be utilized by the cell as a means of functionally regulating chromatin structure and gene expression. At the same time, this double-layered membrane system constitutes a formidable obstacle to the unimpeded flow of genetic information between the genome and the rest of the cell. The nuclear pore has been long considered the sole passageway between nucleus and cytoplasm. A new report challenges this view and proposes a novel mechanism by which RNA transcripts destined for localized translation in highly polarized cell types, cross both inner and outer nuclear envelope membranes and reach the cytoplasm without utilizing the nuclear pore route.en-USThis is an Open Access article licensed under a <a href="http://creativecommons.org/licenses/by-nc/3.0/">Creative Commons Attribution-NonCommercial 3.0 Unported License</a>. The article may redistributed, reproduced and reused for non-commercial purposes, provided the original source is properly cited.Nuclear EnvelopeNuclear Porenuclear envelopenuclear laminanuclear pore complexWnt sig-nalingneuromuscular junctionsRNA exportCellsGenetic PhenomenaMolecular BiologyMolecular GeneticsNucleic Acids, Nucleotides, and NucleosidesResponse or Commenthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1171&amp;context=faculty_pubs&amp;unstamped=1https://escholarship.umassmed.edu/faculty_pubs/1724297382faculty_pubs/172