Gruntman, Alisha MFlotte, Terence R.2022-08-232022-08-232017-07-282017-08-28Methods Mol Biol. 2017;1639:267-275. doi: 10.1007/978-1-4939-7163-3_27. <a href="https://doi.org/10.1007/978-1-4939-7163-3_27">Link to article on publisher's site</a>1064-3745 (Linking)10.1007/978-1-4939-7163-3_2728752467https://hdl.handle.net/20.500.14038/43589This review seeks to give an overview of alpha-1 antitrypsin deficiency, including the different disease phenotypes that it encompasses. We then describe the different therapeutic endeavors that have been undertaken to address these different phenotypes. Lastly we discuss future potential therapeutics, such as genome editing, and how they may play a role in treating alpha-1 antitrypsin deficiency.en-USCRISPR/Cas9EmphysemaGenome editingLiver diseaseSERPINA1Genetics and GenomicsMolecular BiologyTherapeuticsBook Chapterhttps://escholarship.umassmed.edu/peds_pp/15910667370peds_pp/159