Hare, Megan M.Kroll-Desrosiers, AimeeDeligiannidis, Kristina M.2022-08-232022-08-232021-04-012021-06-14<p>Hare MM, Kroll-Desrosiers A, Deligiannidis KM. Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support? Depress Anxiety. 2021 Apr;38(4):390-399. doi: 10.1002/da.23121. Epub 2020 Dec 7. PMID: 33615587; PMCID: PMC8026554. <a href="https://doi.org/10.1002/da.23121">Link to article on publisher's site</a></p>1091-4269 (Linking)10.1002/da.2312133615587https://hdl.handle.net/20.500.14038/50417BACKGROUND: Peripartum depression (PND) impairs mother-infant boding and perceived social support, yet limited research has examined if women at-risk for PND (AR-PND) also experience impairment. We examined if pregnant women AR-PND, women with PND, and healthy comparison women (HCW) differed in their mother-infant bonding and social support. As PND is highly comorbid with anxiety, we also examined if peripartum anxiety impacted postpartum diagnosis of PND. METHODS: A total of 144 pregnant women AR-PND or euthymic were assessed twice antepartum and twice postpartum. We utilized regression models to examine the impact of PND risk group status and diagnostic status on mother-infant bonding and perceived social support postpartum. We conducted a sensitivity analysis using a generalized estimating equations model to determine if anxiety (Hamilton Anxiety Rating Scale, HAM-A) across all four time points was associated with the postpartum diagnosis of PND. RESULTS: Women AR-PND experienced significantly worse mother-infant bonding compared to HCW (p = .03). Women diagnosed with PND experienced significantly worse mother-infant bonding and social support compared to HCW (p = .001, p = .002, respectively) and to those who were at-risk for but did not develop PND (p = .02, p = .008, respectively). HAM-A severity at each visit was associated with PND diagnosis status, where each increase in HAM-A was associated with 15% increased odds of being diagnosed with PND postpartum. CONCLUSIONS: Both women AR-PND and those with PND experience worse mother-infant bonding. Peripartum anxiety should also be assessed as it represents a marker for later PND.en-USanxietydepressionmother-infant relationshipperipartumpostpartumsocial supportUMCCTS fundingDiagnosisMaternal and Child HealthObstetrics and GynecologyPsychiatryPsychiatry and PsychologyTranslational Medical ResearchWomen's HealthJournal Articlehttps://escholarship.umassmed.edu/umccts_pubs/24023348945umccts_pubs/240