Brunner, Robert L.Dunbar-Jacob, JacquelineLeBoff, Meryl S.Granek, I.Bowen, Deborah J.Snetselaar, Linda G.Shumaker, Sally A.Ockene, Judith K.Rosal, Milagros CWactawski-Wende, JeanCauley, Jane A.Cochrane, Barbara B.Tinker, Lesley F.Jackson, Rebecca D.Wang, C. Y.Wu, L.2022-08-232022-08-232009-12-012010-03-03<p>Behav Med. 2009 Winter;34(4):145-55. <a href="http://dx.doi.org/10.3200/BMED.34.4.145-155">Link to article on publisher's site</a></p>0896-4289 (Linking)10.3200/BMED.34.4.145-15519064373https://hdl.handle.net/20.500.14038/50963The authors analyzed data from the Women's Health Initiative (WHI) Calcium and Vitamin D Supplementation Trial (CaD) to learn more about factors affecting adherence to clinical trial study pills (both active and placebo). Most participants (36,282 postmenopausal women aged 50-79 years) enrolled in CaD 1 year after joining either a hormone trial or the dietary modification trial of WHI. The WHI researchers measured adherence to study pills by weighing the amount of remaining pills at an annual study visit; adherence was primarily defined as taking > or = 80% of the pills. The authors in this study examined a number of behavioral, demographic, procedural, and treatment variables for association with study pill adherence. They found that relatively simple procedures (ie, phone contact early in the study [4 weeks post randomization] and direct social contact) later in the trial may improve adherence. Also, at baseline, past pill-use experiences, personal supplement use, and relevant symptoms may be predictive of adherence in a supplement trial.en-USAgedAttitude to HealthCalcium, Dietary*Dietary SupplementsDouble-Blind MethodFemaleForecastingHumansLongitudinal StudiesMedication AdherenceMiddle AgedPostmenopauseRisk FactorsVitamin D*Women's HealthLife SciencesMedicine and Health SciencesWomen's StudiesJournal Articlehttps://escholarship.umassmed.edu/wfc_pp/4931192100wfc_pp/493