Welsh, Raymond M.Waggoner, Stephen N.2022-08-232022-08-232013-01-052013-10-08Virology. 2013 Jan 5;435(1):37-45. doi: 10.1016/j.virol.2012.10.005. <a href="http://dx.doi.org/10.1016/j.virol.2012.10.005">Link to article on publisher's website</a>1096-034110.1016/j.virol.2012.10.00523217614https://hdl.handle.net/20.500.14038/30020Viral infections characteristically induce a cytokine-driven activated natural killer (NK) cell response that precedes an antigen-driven T cell response. These NK cells can restrain some but not all viral infections by attacking virus-infected cells and can thereby provide time for an effective T cell response to mobilize. Recent studies have revealed an additional immunoregulatory role for the NK cells, where they inhibit the size and functionality of the T cell response, regardless of whether the viruses are themselves sensitive to NK cells. This subsequent change in T cell dynamics can alter patterns of immunopathology and persistence and implicates NK cells as rheostat-like regulators of persistent infections.en-USAcute DiseaseAnimalsChronic DiseaseHerpesviridae InfectionsHumansImmunity, HumoralImmunity, InnateImmunomodulationKiller Cells, NaturalLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMuromegalovirusReceptors, Natural Killer CellT-LymphocytesImmunology of Infectious DiseaseImmunopathologyVirologyJournal Articlehttps://escholarship.umassmed.edu/faculty_pubs/2534683145faculty_pubs/253