Bach, Ingolf2022-08-232022-08-232012-06-262012-08-09Cell Res. 2012 Jun 26. doi: 10.1038/cr.2012.98. <a href="http://dx.doi.org/10.1038/cr.2012.98">Link to article on publisher's site</a>1001-0602 (Linking)10.1038/cr.2012.9822785560https://hdl.handle.net/20.500.14038/43994One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.en-USX Chromosome InactivationGenetics and GenomicsJournal Articlehttps://escholarship.umassmed.edu/pgfe_pp/2023194127pgfe_pp/202