Muntner, PaulNewsome, Britt B.Kramer, HollyPeralta, Carmen A.Kim, YonginJacobs, David R. Jr.Kiefe, Catarina I.Lewis, Cora E.2022-08-232022-08-232012-01-132012-10-15Clin J Am Soc Nephrol. 2012 Jan;7(1):101-7. Epub 2011 Nov 10. DOI 10.2215/CJN.06450611. <a href="http://dx.doi.org/10.2215/CJN.06450611" target="_blank">Link to article on publisher's site</a>1555-9041 (Linking)10.2215/CJN.0645061122076879https://hdl.handle.net/20.500.14038/46550BACKGROUND AND OBJECTIVES: The incidence of ESRD is higher in African Americans than in whites, despite reports of a similar or lower prevalence of CKD. DESIGN, SETTING, PARTICIPANTS, and MEASUREMENTS: This study compared the incidence of CKD among young African-American and white adults over 20 years of follow-up in the community-based Coronary Artery Risk Development in Young Adults study. Participants included 4119 adults, 18-30 years of age, with an estimated GFR (eGFR) >/=60 ml/min per 1.73 m(2) at baseline. Incident CKD was defined as an eGFR /min per 1.73 m(2) and a >/=25% decline in eGFR at study visits conducted 10, 15, and 20 years after baseline. RESULTS: At baseline, the mean age of African Americans and whites was 24 and 26 years, respectively (P<0.001), and 56% and 53% of participants, respectively, were women (P=0.06). There were 43 incident cases of CKD during follow-up, 29 (1.4%) among African Americans and 14 (0.7%) among whites (P=0.02). The age- and sex-adjusted hazard ratio (HR) for incident CKD comparing African Americans to whites was 2.56 (95% confidence interval [95% CI], 1.35-5.05). After further adjustment for body mass index, systolic BP, fasting plasma glucose, and HDL cholesterol, the HR was 2.51 (95% CI, 1.25-5.05). After multivariable adjustment including albuminuria at year 10, the HR for CKD at year 15 or 20 was 1.12 (95% CI, 0.52-2.41). CONCLUSIONS: In this study, the 20-year CKD incidence was higher among African Americans than whites, a difference that is explained in part by albuminuria.en-USAdultAfrican AmericansAlbuminuriaChronic DiseaseEuropean Continental Ancestry GroupFemaleGlomerular Filtration RateHumansIncidenceKidney DiseasesKidney Failure, ChronicMaleYoung AdultBiostatisticsEpidemiologyFemale Urogenital Diseases and Pregnancy ComplicationsHealth Services ResearchMale Urogenital DiseasesJournal Articlehttps://escholarship.umassmed.edu/qhs_pp/10163393448qhs_pp/1016