Luciano, Amelia K.Guertin, David A.2022-08-232022-08-232019-02-012019-07-18<p>Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. <a href="https://doi.org/10.1038/s41556-019-0275-8">Link to article on publisher's site</a></p>1465-7392 (Linking)10.1038/s41556-019-0275-830692624https://hdl.handle.net/20.500.14038/44387AKT, also known as protein kinase B, is one of the most frequently dysregulated serine/threonine kinases in cancer, and its hyperactivity drives tumorigenesis and chemotherapy resistance. Two studies now find that AKT methylation by the methyltransferase SETDB1 is an early step in its oncogenic activation.en-USCancerGrowth factor signallingMethylationUbiquitylationCancer BiologyCell BiologyCellular and Molecular PhysiologyJournal Articlehttps://escholarship.umassmed.edu/pmm_pp/11414954526pmm_pp/114