Zheng, JialiTabung, Fred K.Zhang, JiajiaMurphy, E. AngelaShivappa, NitinOckene, Judith K.Caan, BetteKroenke, Candyce H.Hebert, James R.Steck, Susan E.2022-08-232022-08-232019-04-062019-08-02<p>Eur J Nutr. 2019 Apr 6. doi: 10.1007/s00394-019-01956-z. <a href="https://doi.org/10.1007/s00394-019-01956-z">Link to article on publisher's site</a></p>1436-6207 (Linking)10.1007/s00394-019-01956-z30955051https://hdl.handle.net/20.500.14038/44541PURPOSE: Dietary factors may influence colorectal cancer (CRC) survival through effects on inflammation. We examined the association between post-CRC diagnosis inflammatory potential of diet and all-cause and cancer-specific mortality in the Women's Health Initiative. METHODS: The study included 463 postmenopausal women who developed CRC during follow-up and completed a food frequency questionnaire (FFQ), on average 1.7 years after diagnosis. Women were followed from CRC diagnosis until death, censoring, or the end of follow-up in October 2014. Energy-adjusted dietary inflammatory index (E-DII)((R)) scores were calculated from the FFQ and dietary supplement inventory. Cox proportional hazards models were fitted to estimate multivariable-adjusted HRs and 95% confidence intervals (CIs) for all-cause, total cancer, and CRC-specific mortality with the most pro-inflammatory E-DII scores (tertile 3) as referent. RESULTS: After a median 11.6 years of follow-up, 162 deaths occurred, including 77 from CRC. Lowest tertile (i.e., most anti-inflammatory) E-DII scores from diet plus supplements were associated with significantly lower all-cause mortality (HRT1vsT3 = 0.49; 95% CI 0.31-0.79) compared to the most pro-inflammatory E-DII tertile. Modest associations with total cancer mortality or CRC-specific mortality were observed, though 95% CIs included 1. CONCLUSIONS: Consuming a dietary pattern and supplements with more anti-inflammatory potential after CRC diagnosis may improve overall survival among postmenopausal women.en-USPost-cancer diagnosisDietary patternColorectal cancer survivalCohort studyPostmenopausal womenCommunity Health and Preventive MedicineDietetics and Clinical NutritionNeoplasmsPreventive MedicineWomen's HealthJournal Articlehttps://escholarship.umassmed.edu/prc_pubs/13515045312prc_pubs/135