Piriou, ErwanKimmel, RhondaChelimo, KiprotichMiddeldorp, Jaap M.Sumba, Peter OdadaPloutz-Snyder, RobertMoormann, Ann M.Rochford, Rosemary A.2022-08-232022-08-232009-04-222010-06-08J Med Virol. 2009 Jun;81(6):1088-93. <a href="http://dx.doi.org/10.1002/jmv.21485">Link to article on publisher's site</a>0146-6615 (Linking)10.1002/jmv.2148519382256https://hdl.handle.net/20.500.14038/47268To study the long term the effects of chronic exposure to P. falciparum malaria on Epstein-Barr virus (EBV) reactivation in children, EBV-specific antibody levels were measured in a cross-sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1-4 years, 5-9 years and 10-14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV-specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation.en-USAdolescentAntibodies, ViralAntigens, ViralChildChild, PreschoolCross-Sectional StudiesEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHumansImmunoglobulin GInfantKenyaMalaria*Virus ActivationBiostatisticsEpidemiologyHealth Services ResearchImmunology and Infectious DiseasePediatricsJournal Articlehttps://escholarship.umassmed.edu/qhs_pp/4091347940qhs_pp/409