Werneburg, SebastianFeinberg, Philip AJohnson, Kasey M.Schafer, Dorothy P2022-08-232022-08-232017-12-012017-11-30Curr Opin Neurobiol. 2017 Dec;47:138-145. doi: 10.1016/j.conb.2017.10.002. Epub 2017 Nov 6. <a href="https://doi.org/10.1016/j.conb.2017.10.002">Link to article on publisher's site</a>0959-4388 (Linking)10.1016/j.conb.2017.10.00229096242https://hdl.handle.net/20.500.14038/37943<p>Philip Feinberg is a student in the MD/PhD Program in the Morningside Graduate School of Biomedical Sciences at UMass Medical School.</p>Microglia have recently been recognized as key regulators of synapse development, function, and plasticity. Critical to progressing the field is the identification of molecular underpinnings necessary for microglia to carry out these important functions within neural circuits. Here, we focus a review specifically on roles for microglial cytokine signaling within developing and mature neural circuits. We review exciting new studies demonstrating essential roles for microglial cytokine signaling in axon outgrowth, synaptogenesis and synapse maturation during development, as well as synaptic transmission and plasticity in adulthood. Together, these studies identify microglia and cytokines as critical modulators of neural circuits within the healthy brain, with implications for a broad range of neurological disorders with disruptions in synaptic structure and function.en-USNeuroscience and NeurobiologyJournal Articlehttps://escholarship.umassmed.edu/neurobiology_pp/21611176560neurobiology_pp/216