Klionsky, Daniel J.Baehrecke, Eric H.Galluzzi, LorenzoPietrocola, Federico2022-08-232022-08-232021-10-012022-02-28<p>Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Autophagy in major human diseases. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. PMID: 34459017; PMCID: PMC8488577. <a href="https://doi.org/10.15252/embj.2021108863">Link to article on publisher's site</a></p>0261-4189 (Linking)10.15252/embj.202110886334459017https://hdl.handle.net/20.500.14038/42082<p>Full author list omitted for brevity. For the full list of authors, see article.</p>Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.en-USCopyright © 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/agingcancerinflammationmetabolic syndromesneurodegenerationBiological Phenomena, Cell Phenomena, and ImmunityCell BiologyCellular and Molecular PhysiologyAutophagy in major human diseasesJournal Articlehttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5919&context=oapubs&unstamped=1https://escholarship.umassmed.edu/oapubs/488528282627oapubs/4885