van der Bom, I. M. J.Moser, Richard P.Gao, GuangpingMondo, EricaO'Connell, DeniceGounis, Matthew JMcGowan, SarahChaurette, J.Bishop, N.Sena-Esteves, MiguelMueller, ChristianAronin, Neil2022-08-232022-08-232013-01-012017-06-07J Huntingtons Dis. 2013;2(1):41-5. doi: 10.3233/JHD-130053. <a href="https://doi.org/10.3233/JHD-130053">Link to article on publisher's site</a>1879-6397 (Linking)10.3233/JHD-13005325063428https://hdl.handle.net/20.500.14038/48171Our goal is delivery of a long-term treatment for Huntington's disease. We administer intracerebrally in sheep adeno-associated virus (AAV) to establish optimal safety, spread and neuronal uptake of AAV based therapeutics. Sheep have large gyrencephalic brains and offer the opportunity to study a transgenic Huntington's disease model. However, lack of a relevant brain stereotactic atlas and the difficulty of skull fixation make conventional stereotaxy unreliable. We describe a multi-modal image-guidance technique to achieve accurate placement of therapeutics into the sheep striatum.en-USSheep brainhuntingtin therapeuticsstereotaxis placementAnimal SciencesNervous System DiseasesRadiologyTherapeuticsJournal Articlehttps://escholarship.umassmed.edu/radiology_pubs/28710265300radiology_pubs/287