Cable, Edward EarlGreene, Yvonne J.Healey, John F.Evans, Chheng-OrnBonkovsky, Herbert L.2022-08-232022-08-231990-04-162008-08-14Biochem Biophys Res Commun. 1990 Apr 16;168(1):176-81.0006-291X (Print)2327996https://hdl.handle.net/20.500.14038/33063Heme oxygenase, the rate controlling enzyme for heme catabolism, is inducible by a variety of treatments, some of which induce by a heme-dependent mechanism and others by a heme-independent mechanism. This work shows that, in cultured chick embryo liver cells, synergistic induction of heme oxygenase by iron, added with the phenobarbital-like drug, glutethimide was heme-dependent. Addition of an inhibitor of heme biosynthesis abolished the synergistic induction of heme oxygenase providing evidence for the heme-dependent mechanism of induction. Glutethimide and iron appeared to induce at the transcriptional level since both heme oxygenase mRNA and protein levels correlate with changes in heme oxygenase activity.en-USJournal Articlehttps://escholarship.umassmed.edu/gsbs_sp/161578125gsbs_sp/161