Barras, FredericMarinus, Martin G.2022-08-232022-08-231989-05-012009-01-12Trends Genet. 1989 May;5(5):139-43.0168-9525 (Print)2667217https://hdl.handle.net/20.500.14038/26093In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.en-USBase SequenceChromosomes, BacterialDNA Modification MethylasesDNA ReplicationDNA, BacterialEscherichia coliGene Expression RegulationMethylationBiochemistry, Biophysics, and Structural BiologyPharmacology, Toxicology and Environmental HealthJournal Articlehttps://escholarship.umassmed.edu/bmp_pp/33692449bmp_pp/33