Brown, Kirk M.Chu, Chia-yingRana, Tariq M.2022-08-232022-08-232005-04-272008-08-11Nat Struct Mol Biol. 2005 May;12(5):469-70. Epub 2005 Apr 24. <a href="http://dx.doi.org/10.1038/nsmb931">Link to article on publisher's site</a>1545-9993 (Print)10.1038/nsmb93115852021https://hdl.handle.net/20.500.14038/32776In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC(*)) catalysis. Kinetic studies revealed that siRNA-programmed RISC(*) cleaved target RNA with higher efficiencies when target site access was increased. These results provide evidence that target site access is linked to RISC(*) catalysis.en-USJournal Articlehttps://escholarship.umassmed.edu/gsbs_sp/133573959gsbs_sp/133