Li, YunlongSu, YinxiaZhang, YangchangGuo, ZihaoChen, ZhaoyunLi, HuiZhang, ChunyangChi, QiaogeGe, YangJavanbakht, MohammadMusa, Salihu SSun, ShengzhiTang, NaijunWang, KaiWang, KailuZhao, Shi2025-05-192025-05-192025-05-15Li Y, Su Y, Zhang Y, Guo Z, Chen Z, Li H, Zhang C, Chi Q, Ge Y, Javanbakht M, Musa SS, Sun S, Tang N, Wang K, Wang K, Zhao S. Association between inactivated COVID-19 vaccine and semen quality among males recovered from omicron infection: a retrospective cohort study. Expert Rev Clin Immunol. 2025 May 15. doi: 10.1080/1744666X.2025.2507329. Epub ahead of print. PMID: 40372240.1744-840910.1080/1744666X.2025.250732940372240https://hdl.handle.net/20.500.14038/54438Background: The protective effects of inactivated COVID-19 vaccines against SARS-CoV-2-associated semen impairment remain underexplored. We investigated associations between BBIBP-CorV vaccination and the semen quality in males recovering from SARS-CoV-2 infection. Research design and methods: This single-center retrospective cohort study included 1,496 males recovering from SARS-CoV-2 infection at a tertiary hospital in Urumqi, China (February-May 2023). Participants were categorized into long-term and short-term effects groups based on the interval between semen collection and their most recent SARS-CoV-2 infection. The study assessed the association between the different doses of BBIBP-CorV vaccination and semen quality in both groups. Results: A total of 1496 participants were recruited for the short-term (n = 307) and long-term effect groups (n = 1189). Participants had a median age of 32 (IQR: 30, 35). Compared to unvaccinated controls, 2-dose and 3-dose recipients showed reduced short-term semen quality impairment risks, with adjusted RR of 0.945 (95% CI 0.918, 0.973) and 0.965 (95% CI 0.937, 0.993), respectively. No significant results were found for long-term effect groups. Conclusion: Inactivated COVID-19 vaccination may protect against semen quality impairment among males recovering from SARS-CoV-2 Omicron infection within 90 days, especially in terms of semen volume and sperm progressive motility.enJournal Article