Yen, KelvinNarasimhan, Sri DeviTissenbaum, Heidi A.2022-08-232022-08-232011-02-152011-04-19Antioxid Redox Signal. 2011 Feb 15;14(4):623-34. Epub 2010 Nov 30. <a href="http://dx.doi.org/10.1089/ars.2010.3490">Link to article on publisher's site</a>1523-0864 (Linking)10.1089/ars.2010.349020673162https://hdl.handle.net/20.500.14038/44059The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes.en-US<p>This is a copy of an article published in Antioxidants & Redox Signaling © 2010 Mary Ann Liebert, Inc. and available online at: http://www.liebertonline.com.</p>Caenorhabditis elegans ProteinsTranscription FactorsForkhead Transcription FactorsInsulin-Like Growth Factor IReceptor, IGF Type 1Genetics and GenomicsJournal Articlehttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1034&amp;context=pgfe_pp&amp;unstamped=1https://escholarship.umassmed.edu/pgfe_pp/341946687pgfe_pp/34