Vaishnav, DhrumilEssibayi, Muhammed AmirMusmar, BaselAdeeb, NimerSalim, Hamza AdelAslan, AssalaCancelliere, Nicole MMcLellan, Rachel MAlgin, OktayGhozy, SheriefLay, Sovann VGuenego, AdrienRenieri, LeonardoCarnevale, JosephSaliou, GuillaumeMastorakos, PanagiotisEl Naamani, KareemShotar, EimadPremat, KevinMöhlenbruch, MarkusKral, MichaelDoron, OmerChung, CharlotteSalem, Mohamed MLylyk, IvanForeman, Paul MVachhani, Jay AShaikh, HamzaŽupančić, VedranHafeez, Muhammad UCatapano, JoshuaWaqas, MuhammadAyberk, GiyasCelal Gunes, YasinRabinov, James DRen, YifanSchirmer, Clemens MPiano, MariangelaKühn, Anna LMichelozzi, CaterinaElens, StéphanieStarke, Robert MHassan, Ameer EOgilvie, MarkNguyen, AnhJones, JesseBrinjikji, WaleedNawka, Marie TPsychogios, MariosUlfert, ChristianDiestro, Jose Danilo BengzonPukenas, BryanBurkhardt, Jan-KarlHuynh, ThienMartinez-Gutierrez, Juan CarlosSheth, Sunil ASpiegel, GaryTawk, Rabih GLubicz, BorisPanni, PietroPuri, Ajit SPero, GuglielmoNossek, ErezRaz, EytanKiller-Oberpfalzer, MonikaGriessenauer, Christoph JAsadi, HamedSiddiqui, AdnanBrook, Allan LHaranhalli, NeilDucruet, Andrew FAlbuquerque, Felipe CRegenhardt, Robert WStapleton, Christopher JKan, PeterKalousek, VladimirLylyk, PedroBoddu, SrikanthKnopman, JaredAziz-Sultan, Mohammad ATjoumakaris, Stavropoula IClarençon, FrédéricLimbucci, NicolaCuellar-Saenz, Hugo HJabbour, Pascal MMendes Pereira, VitorPatel, Aman BAltschul, David JDmytriw, Adam A2025-02-032025-02-032025-01-31Vaishnav D, Essibayi MA, Musmar B, Adeeb N, Salim HA, Aslan A, Cancelliere NM, McLellan RM, Algin O, Ghozy S, Lay SV, Guenego A, Renieri L, Carnevale J, Saliou G, Mastorakos P, El Naamani K, Shotar E, Premat K, Möhlenbruch M, Kral M, Doron O, Chung C, Salem MM, Lylyk I, Foreman PM, Vachhani JA, Shaikh H, Župančić V, Hafeez MU, Catapano J, Waqas M, Ayberk G, Celal Gunes Y, Rabinov JD, Ren Y, Schirmer CM, Piano M, Kühn AL, Michelozzi C, Elens S, Starke RM, Hassan AE, Ogilvie M, Nguyen A, Jones J, Brinjikji W, Nawka MT, Psychogios M, Ulfert C, Diestro JDB, Pukenas B, Burkhardt JK, Huynh T, Martinez-Gutierrez JC, Sheth SA, Spiegel G, Tawk RG, Lubicz B, Panni P, Puri AS, Pero G, Nossek E, Raz E, Killer-Oberpfalzer M, Griessenauer CJ, Asadi H, Siddiqui A, Brook AL, Haranhalli N, Ducruet AF, Albuquerque FC, Regenhardt RW, Stapleton CJ, Kan P, Kalousek V, Lylyk P, Boddu S, Knopman J, Aziz-Sultan MA, Tjoumakaris SI, Clarençon F, Limbucci N, Cuellar-Saenz HH, Jabbour PM, Mendes Pereira V, Patel AB, Altschul DJ, Dmytriw AA; WorldWideWEB Consortium. Impact of smoking on recurrence rates among wide-neck intracranial aneurysms treated with Woven EndoBridge: a multicenter retrospective study. J Neurosurg. 2025 Jan 31:1-9. doi: 10.3171/2024.10.JNS241058. Epub ahead of print. PMID: 39889291.1933-069310.3171/2024.10.JNS24105839889291https://hdl.handle.net/20.500.14038/54123Objective: Tobacco smoking is among the factors known to significantly augment the risk of untreated intracranial aneurysm (IA) growth and rupture. Smoking appears to have a variable effect on different endovascular treatment modalities. The impact of smoking on the safety, efficacy, and outcomes of Woven EndoBridge (WEB) device use for wide-neck IAs has not been evaluated. This study aimed to investigate the outcomes of WEB devices by smoking status. Methods: A retrospective multicenter analysis was conducted on the data of patients from 36 sites worldwide treated with the WEB device for intracranial saccular aneurysms. Patients were stratified based on smoking status (current, former, and never smokers). The Student t-test and chi-square test were performed for continuous and categorical variables, respectively. Multivariable logistic regression was used to adjust for confounders. Results: Of 1376 patients with available smoking status, 504 were current smokers, 358 were former smokers, and 514 were never smokers. Upon adjusting for significant confounders, no association was found between smoking and recurrence outcomes (OR 1.39, 95% CI 0.69-2.80; p = 0.36), thromboembolic and hemorrhagic complications, and mortality among IAs treated with the WEB device. There was no statistically significant difference in outcomes between former and never smokers (OR 1.23, 95% CI 0.70-2.18; p = 0.46). The location of aneurysms differed between smoking groups, with former smokers having more anterior circulation aneurysms compared with current and never smokers (99.0% vs 96.9% vs 95.3%; p = 0.01). In terms of clinical symptoms, headache and dizziness were more common in the never smokers compared with current and former smokers (13.9% vs 8.9% vs 7.7%, p = 0.01). Conclusions: This large-scale study suggests no significant correlation between smoking and the recurrence of IAs treated with the WEB device. Biological studies are warranted to better understand the biological impact of smoking on the growth and rupture of treated IAs.enWEBWoven EndoBridgeaneurysmsintracranialsmokingvascular disordersJournal Article