Selin, Liisa K.Lin, Meei-YunKraemer, Kristy A.Pardoll, Drew M.Schneck, Jonathan P.Varga, Steven MichaelSantolucito, Paul A.Pinto, Amelia K.Welsh, Raymond M.2022-08-232022-08-232000-01-082008-12-10<p>Immunity. 1999 Dec;11(6):733-42.</p>1074-7613 (Print)10.1016/S1074-7613(00)80147-810626895https://hdl.handle.net/20.500.14038/32520Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.en-USJournal Articlehttps://escholarship.umassmed.edu/gsbs_sp/1088679626gsbs_sp/1088