Imbalzano, Anthony N.Jones, Stephen N.2022-08-232022-08-232005-04-202011-01-28Cancer Cell. 2005 Apr;7(4):294-5. <a href="http://dx.doi.org/10.1016/j.ccr.2005.04.001">Link to article on publisher's site</a>1535-6108 (Linking)10.1016/j.ccr.2005.04.001https://hdl.handle.net/20.500.14038/36018SNF5 is a core subunit of the SWI/SNF chromatin-remodeling complex. Mammalian SNF5 is essential for normal cell viability, and loss or mutation of the human SNF gene is the molecular basis for familial malignant rhabdoid tumorigenesis. Previous studies have suggested that SNF5 suppresses cancer by signaling through the p16Ink4a and retinoblastoma tumor suppressors to negatively regulate cell cycle progression from G0/G1 into S phase. A recent paper in Genes and Development (Vries et al., 2005) reports that human SNF5 also signals via the p16INK4a-Rb-E2F pathway to regulate chromosomal stability, suggesting a new function for this chromatin remodeling protein in tumor suppression.en-USAneuploidyAnimalsCell CycleCell Cycle ProteinsChromatin Assembly and DisassemblyChromosomal InstabilityChromosomal Proteins, Non-HistoneCyclin D1Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent KinasesDNA-Binding ProteinsE2F Transcription FactorsHumansModels, BiologicalPhosphorylationPolyploidyProto-Oncogene ProteinsRetinoblastoma ProteinRhabdoid TumorTranscription FactorsTumor Suppressor ProteinsCell BiologyJournal Articlehttps://escholarship.umassmed.edu/jones/211750955jones/21