Rutherford, Helena JvKim, SohyeYip, Sarah WPotenza, Marc NMayes, Linda CStrathearn, Lane2022-12-152022-12-152021-07-09Rutherford HJ, Kim S, Yip SW, Potenza MN, Mayes LC, Strathearn L. Parenting and addictions: Current insights from human neuroscience. Curr Addict Rep. 2021 Sep;8(3):380-388. doi: 10.1007/s40429-021-00384-6. Epub 2021 Jul 9. PMID: 36185758; PMCID: PMC9523670.2196-295210.1007/s40429-021-00384-636185758https://hdl.handle.net/20.500.14038/51464Purpose: A growing body of human research has documented associations between the maternal brain and maternal substance use and addictions. This neuroscience-informed approach affords the opportunity to unpack potential neurobiological mechanisms that may underscore challenges in maternal caregiving behavior among mothers with addictions and provide new directions for parenting interventions. Findings: Consistent with theoretical models of parenting and addictions, five studies evidence both hypo- and hyper-reactivity to infant affective cues across neuroimaging methods and tasks that incorporate both infant face and cry stimuli. Three structural and resting-state brain studies as a function of maternal substance use are also reported. Conclusions: While human neuroimaging research converges in showing that maternal substance use is associated with differential reactivity to infant affective cues, further multi-level/multi-modal, longitudinal, and dimensional research is critically needed to advance this area of investigation.enEEG/ERPaddictive behaviorsfMRIinfant cuesmotherssubstance useUMCCTS fundingJournal ArticleCurrent addiction reports