Bandaranayake, Rajintha M.Prabu-Jeyabalan, MosesKakizawa, JunkoSugiura, WataruSchiffer, Celia A.2022-08-232022-08-232008-07-012009-07-08J Virol. 2008 Jul;82(13):6762-6. <a href="http://dx.doi.org/10.1128/JVI.00018-08">Link to article on publisher's website</a>1098-551410.1128/JVI.00018-081843439218434392https://hdl.handle.net/20.500.14038/33046The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease compared to the clade B protease structure.en-USJournal Articlehttps://escholarship.umassmed.edu/gsbs_sp/1595891185gsbs_sp/1595