Farren, Connor K.Ziedonis, Douglas M.Clare, Anthony W.Hammeedi, Faiq A.Dinan, Timothy G.2022-08-232022-08-231995-12-012010-08-28Alcohol Clin Exp Res. 1995 Dec;19(6):1578-82.0145-6008 (Linking)8749830https://hdl.handle.net/20.500.14038/45633Serum prolactin response to the serotonin agonist D-fenfluramine were measured in 19 DSM-111-R male alcoholics, 2.5 or more weeks postalcohol withdrawal. Prolactin responses were compared with nine healthy nonalcoholic male controls. After an overnight fast, each subject received 30 mg of D-fenfluramine orally, and serial samples of serum prolactin were taken over a 4-hr period. D-fenfluramine caused a significantly attenuated peak delta-prolactin response in the alcoholics relative to the controls (p = 0.05). A repeated-measures ANOVA of delta-prolactin yielded a significant within-subjects effect of time (p < 0.05), a within-subjects effect of group that reached significance (p = 0.05), and a nonsignificant group by time interaction. The delta-prolactin value at time points 60 and 240 min postadministration of the probe was significantly attenuated in the alcoholic group, with p < 0.05. There was also some evidence for a diminished serotonergic response in those alcoholics with a negative family history. The delta-prolactin response did not correlate with subjects' age, duration of alcohol use, duration of abstinence from alcohol, severity of alcohol dependence, or age of onset. Results imply a relative subsensitivity of the serotonin system in postwithdrawal alcoholics, and this may be primarily of the 5-HT2 receptor.en-USAdultAlcohol Withdrawal DeliriumAlcoholismFenfluramineGenotypeHumansMaleMiddle AgedProlactinReceptors, SerotoninReference ValuesTemperancePsychiatryJournal Articlehttps://escholarship.umassmed.edu/psych_pp/1671482968psych_pp/167