Faust, Travis ESchafer, Dorothy P2022-08-232022-08-232021-11-092021-12-20<p>Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. <a href="https://doi.org/10.1016/j.immuni.2021.10.010">Link to article on publisher's site</a></p>1074-7613 (Linking)10.1016/j.immuni.2021.10.01034758335https://hdl.handle.net/20.500.14038/29925Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.en-USAmino Acids, Peptides, and ProteinsDevelopmental NeuroscienceImmunityMolecular and Cellular NeuroscienceJournal Articlehttps://escholarship.umassmed.edu/faculty_pubs/212826908867faculty_pubs/2128