Major, Jacqueline M.Doubeni, Chyke A.Freedman, Neal D.Park, YikyungLian, MinHollenbeck, Albert R.Schatzkin, ArthurGraubard, Barry I.Sinha, Rashmi2022-08-232022-08-232010-11-232012-01-26PLoS One. 2010 Nov 23;5(11):e15538. <a href="http://dx.doi.org/10.1371/journal.pone.0015538">Link to article on publisher's site</a>1932-6203 (Linking)10.1371/journal.pone.001553821124858https://hdl.handle.net/20.500.14038/30840PURPOSE: Residing in deprived areas may increase risk of mortality beyond that explained by a person's own SES-related factors and lifestyle. The aim of this study was to examine the relation between neighborhood socioeconomic deprivation and all-cause, cancer- and cardiovascular disease (CVD)-specific mortality for men and women after accounting for education and other important person-level risk factors. METHODS: In the longitudinal NIH-AARP Study, we analyzed data from healthy participants, ages 50-71 years at study baseline (1995-1996). Deaths (n = 33831) were identified through December 2005. Information on census tracts was obtained from the 2000 US Census. Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for quintiles of neighborhood deprivation. RESULTS: Participants in the highest quintile of deprivation had elevated risks for overall mortality (HR(men) = 1.17, 95% CI: 1.10, 1.24; HR(women) = 1.13, 95% CI: 1.05, 1.22) and marginally increased risk for cancer deaths (HR(men) = 1.09, 95% CI: 1.00, 1.20; HR(women) = 1.09, 95% CI: 0.99, 1.22). CVD mortality associations appeared stronger in men (HR = 1.33, 95% CI: 1.19, 1.49) than women (HR = 1.18, 95% CI: 1.01, 1.38). There was no evidence of an effect modification by education. CONCLUSION: Higher neighborhood deprivation was associated with modest increases in all-cause, cancer- and CVD-mortality after accounting for many established risk factors.en-US<p>This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.</p>AgedCardiovascular DiseasesEducational StatusFemaleHealth StatusHumansLongitudinal StudiesMaleMiddle AgedMortalityMultivariate AnalysisNational Institutes of Health (U.S.)NeoplasmsNutrition AssessmentPrincipal Component AnalysisProportional Hazards ModelsQuestionnaires*Residence CharacteristicsRisk AssessmentRisk FactorsSocial ClassSocioeconomic FactorsUnited StatesCommunity Health and Preventive MedicinePreventive MedicinePrimary CareJournal Articlehttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1168&amp;context=fmch_articles&amp;unstamped=1https://escholarship.umassmed.edu/fmch_articles/1692472581fmch_articles/169